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Reciprocal activation between M1 macrophages and trophoblasts through CXCL9/STAT1/ZEB1/CCL2 axis promotes recurrent spontaneous abortion

BackgroundThe crosstalk between macrophages and trophoblasts plays a crucial role in the development and progression of recurrent spontaneous abortion (RSA). Although M1 macrophages (M1-Mφ) are known to accumulate in RSA decidual tissues, their direct functional impact on trophoblasts remains poorly...

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Principais autores: Sisi Yan, Xiang Wang, Qiuji Wu, Jinli Ding, Hui Qiu
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-11-01
Serier:Frontiers in Immunology
Fag:
recurrent spontaneous abortion
M1-Mφ
trophoblasts
CXCL9
migration and invasion
EMT
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1629370/full
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