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Diminished expression of h2-calponin in prostate cancer cells promotes cell proliferation, migration and the dependence of cell adhesion on substrate stiffness

Calponin is an actin filament-associated protein and its h2 isoform inhibits cell motility. Here we report significant expression of h2-calponin in prostate epithelial cells, which is diminished in cancerous cells. Comparison between a prostate cancer cell line PC3 and its metastatic derivative PC3-...

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Principais autores: M. Moazzem Hossain, Xin Wang, Raymond C. Bergan, J.-P. Jin
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2014-01-01
Serier:FEBS Open Bio
Fag:
H2-calponin
Cytoskeleton
Cell motility
Mechanical regulation
Substrate stiffness
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211546314000588
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