Paclitaxel modulates TGFbeta signaling in scleroderma skin grafts in immunodeficient mice.

BACKGROUND: Systemic sclerosis (SSc) is characterized by excessive fibrosis and obliterative vascular lesions. Abnormal TGFbeta activation is implicated in the pathogenesis of SSc. Aberrant TGFbeta/Smad signaling can be controlled by stabilization of microtubules with paclitaxel. METHODS AND FINDING...

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Prif Awduron:	Xialin Liu, Shoukang Zhu, Tao Wang, Laura Hummers, Fredrick M Wigley, Pascal J Goldschmidt-Clermont, Chunming Dong
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Public Library of Science (PLoS) 2005-12-01
Cyfres:	PLoS Medicine
Mynediad Ar-lein:	http://europepmc.org/articles/PMC1274282?pdf=render
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