Lefty blocks a subset of TGFbeta signals by antagonizing EGF-CFC coreceptors.
Members of the EGF-CFC family play essential roles in embryonic development and have been implicated in tumorigenesis. The TGFbeta signals Nodal and Vg1/GDF1, but not Activin, require EGF-CFC coreceptors to activate Activin receptors. We report that the TGFbeta signaling antagonist Lefty also acts t...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science (PLoS)
2004-02-01
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| Serie: | PLoS Biology |
| Accesso online: | http://europepmc.org/articles/PMC340941?pdf=render |
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