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Promoter activity of Merkel cell Polyomavirus variants in human dermal fibroblasts and a Merkel cell carcinoma cell line

Abstract Background Merkel cell polyomavirus (MCPyV) is a human polyomavirus that establishes a life-long harmless infection in most individuals, with dermal fibroblasts believed to be the natural host cell. However, this virus is the major cause of Merkel cell carcinoma (MCC), an aggressive skin ca...

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Principais autores: Ibrahim Abdulsalam, Kashif Rasheed, Baldur Sveinbjørnsson, Bernhard Ehlers, Ugo Moens
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2020-04-01
Serier:Virology Journal
Fag:
Non-coding control region
Large T-antigen
Luciferase assay
MCC13 cells
MCPyV
Mutations
Online adgang:http://link.springer.com/article/10.1186/s12985-020-01317-x
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