Decoding the role of angiopoietin-like protein 4/8 complex–mediated plasmin generation in the regulation of LPL activity

After feeding, adipose tissue lipoprotein lipase (LPL) activity should be maximized, therefore the potent LPL-inhibitory activity of angiopoietin-like protein 4 (ANGPTL4) must be blocked by ANGPTL8 through formation of ANGPTL4/8 complexes. ANGPTL4/8 tightly binds and protects LPL but also partially...

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Auteurs principaux:	Yan Q. Chen, Eugene Y. Zhen, Anna M. Russell, Mariam Ehsani, Robert W. Siegel, Yuewei Qian, Robert J. Konrad
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2023-10-01
Collection:	Journal of Lipid Research
Sujets:	angiopoietin-like protein (ANGPTL) apolipoprotein (Apo) lipoprotein lipase (LPL) plasmin plasminogen tissue plasminogen activator (tPA)
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S0022227523001141
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