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Notch signaling increases PPARγ protein stability and enhances lipid uptake through AKT in IL‐4‐stimulated THP‐1 and primary human macrophages

Notch signaling and nuclear receptor PPARγ are involved in macrophage polarization, but cross talk between them has not been reported in macrophages. In this study, the effect of Notch signaling on PPARγ in IL‐4‐stimulated human macrophages (M(IL‐4)) was investigated using THP‐1‐derived macrophages...

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Principais autores: Naunpun Sangphech, Pornlapat Keawvilai, Tanapat Palaga
פורמט: Artigo
שפה:Inglês
יצא לאור: Wiley 2020-06-01
סדרה:FEBS Open Bio
נושאים:
AKT
human monocyte‐derived macrophage
IL‐4
Notch signaling
PPARγ
גישה מקוונת:https://doi.org/10.1002/2211-5463.12858
תגים: הוספת תג
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