Dissecting PGE2-driven inhibition of T cell activation using single-cell multi-omic and inflammatory bowel disease genetic association analysis

Abstract Genetic and immunologic studies implicate the interleukin (IL)-23/T helper (Th)17 pathway in inflammatory bowel disease (IBD). IL-23 and IL-1β drive human Th17 differentiation, while prostaglandin E2 (PGE2) and transforming growth factor-β (TGF-β) further modulate Th17 development and plast...

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Principais autores:	Zhongli Xu, Shiyue Tao, Site Feng, Xiangyu Ye, Ting Wang, Haoran Hu, Elisa Heidrich-O’Hare, Wei Chen, Richard H. Duerr
格式:	Artigo
語言:	Inglês
出版:	Nature Portfolio 2026-04-01
叢編:	Nature Communications
在線閱讀:	https://doi.org/10.1038/s41467-026-71383-2
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