Kv1.3 as an upstream regulator of oxidative stress-mediated neuroinflammation following organic dust exposure in murine in vitro, ex vivo, and in vivo models

IntroductionInhalation of organic dust from concentrated animal production operations induces inflammation in the brain and respiratory tract. We investigated the role of the potassium channel Kv1.3 in models of organic dust (OD)-induced neuroinflammation. Kv1.3 channels play multifaceted roles in m...

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Bibliografische Detailangaben

Hauptverfasser:	Nyzil Massey, Sanjana Mahadev Bhat, Denusha Shrestha, Emir Malovic, Locke A. Karriker, Shivani Choudhary, Alan P. Robertson, Hai Minh Nguyen, Heike Wulff, Anumantha G. Kanthasamy, Chandrashekhar Charavaryamath
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2026-03-01
Schriftenreihe:	Frontiers in Toxicology
Schlagworte:	Kv1.3 microglia neuroinflammation organic dust (OD) PAP-1 phosphorylatedp38 MAPK (p-p38 MAPK)
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/ftox.2026.1765108/full
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