Rapid Induction and Maintenance of Virus-Specific CD8+ TEMRA and CD4+ TEM Cells Following Protective Vaccination Against Dengue Virus Challenge in Humans

Dengue virus (DENV) is a mosquito-borne flavivirus that causes serious human disease. The current lack of an effective vaccine to simultaneously protect against the four serotypes of DENV in seronegative individuals is a major unmet medical need. Further, the immunological basis for protective immun...

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Detalhes bibliográficos

Principais autores:	Nancy Graham, Phil Eisenhauer, Sean A. Diehl, Kristen K. Pierce, Stephen S. Whitehead, Anna P. Durbin, Beth D. Kirkpatrick, Alessandro Sette, Daniela Weiskopf, Jonathan E. Boyson, Jason W. Botten
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2020-03-01
coleção:	Frontiers in Immunology
Assuntos:	dengue vaccine CD8 CD4 TEMRA protective immunity
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fimmu.2020.00479/full
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