Teriflunomide Treatment of Multiple Sclerosis Selectively Modulates CD8 Memory T Cells

Background and ObjectivesInhibition of de novo pyrimidine synthesis in proliferating T and B lymphocytes by teriflunomide, a pharmacological inhibitor of dihydroorotate dehydrogenase (DHODH), has been shown to be an effective therapy to treat patients with MS in placebo-controlled phase 3 trials. Ne...

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Detalhes bibliográficos

Principais autores:	Gaëlle Tilly, Marion Cadoux, Alexandra Garcia, Jérémy Morille, Sandrine Wiertlewski, Claire Pecqueur, Sophie Brouard, David Laplaud, Nicolas Degauque
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-10-01
coleção:	Frontiers in Immunology
Assuntos:	multiple sclerosis teriflunomide CD8 T cells CD4 T cells migration memory T cells
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.730342/full
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