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Discovery of a Novel Trifluoromethyl Diazirine Inhibitor of SARS-CoV-2 M<sup>pro</sup>

SARS-CoV-2 M<sup>pro</sup> is a chymotrypsin-like cysteine protease playing a relevant role during the replication and infectivity of SARS-CoV-2, the coronavirus responsible for COVID-19. The binding site of M<sup>pro</sup> is characterized by the presence of a catalytic Cys145 which carries out the...

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Principais autores: Andrea Citarella, Davide Moi, Martina Pedrini, Helena Pérez-Peña, Stefano Pieraccini, Claudio Stagno, Nicola Micale, Tanja Schirmeister, Giulia Sibille, Giorgio Gribaudo, Alessandra Silvani, Daniele Passarella, Clelia Giannini
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-01-01
Serier:Molecules
Fag:
SARS-CoV-2 M<sup>pro</sup>
diazirines
coronavirus
SARS-CoV-2
COVID-19
cysteine proteases
Online adgang:https://www.mdpi.com/1420-3049/28/2/514
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