Discovery of a Novel Trifluoromethyl Diazirine Inhibitor of SARS-CoV-2 M^pro

SARS-CoV-2 M^pro is a chymotrypsin-like cysteine protease playing a relevant role during the replication and infectivity of SARS-CoV-2, the coronavirus responsible for COVID-19. The binding site of M^pro is characterized by the presence of a catalytic Cys145 which carries out the...

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Autores principales:	Andrea Citarella, Davide Moi, Martina Pedrini, Helena Pérez-Peña, Stefano Pieraccini, Claudio Stagno, Nicola Micale, Tanja Schirmeister, Giulia Sibille, Giorgio Gribaudo, Alessandra Silvani, Daniele Passarella, Clelia Giannini
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2023-01-01
Colección:	Molecules
Materias:	SARS-CoV-2 M<sup>pro</sup> diazirines coronavirus SARS-CoV-2 COVID-19 cysteine proteases
Acceso en línea:	https://www.mdpi.com/1420-3049/28/2/514
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