Distinct roles of RAD52 and POLQ in chromosomal break repair and replication stress response.
Disrupting either the DNA annealing factor RAD52 or the A-family DNA polymerase POLQ can cause synthetic lethality with defects in BRCA1 and BRCA2, which are tumor suppressors important for homology-directed repair of DNA double-strand breaks (DSBs), and protection of stalled replication forks. A li...
שמור ב:
| Principais autores: | , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Public Library of Science (PLoS)
2019-08-01
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| סדרה: | PLoS Genetics |
| גישה מקוונת: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1008319&type=printable |
| תגים: |
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