Distinct roles of RAD52 and POLQ in chromosomal break repair and replication stress response.
Disrupting either the DNA annealing factor RAD52 or the A-family DNA polymerase POLQ can cause synthetic lethality with defects in BRCA1 and BRCA2, which are tumor suppressors important for homology-directed repair of DNA double-strand breaks (DSBs), and protection of stalled replication forks. A li...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science (PLoS)
2019-08-01
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| Edice: | PLoS Genetics |
| On-line přístup: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1008319&type=printable |
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