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SARS-CoV-2 Nsp1 mediated mRNA degradation requires mRNA interaction with the ribosome

Nsp1 is a SARS-CoV-2 host shutoff factor that both represses cellular translation and promotes host RNA decay. However, it is unclear how these two activities are connected and interact with normal translation processes. Here, we performed mutational analyses of Nsp1, and these revealed that both th...

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Autors principals: Soraya I. Shehata, Roy Parker
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis Group 2023-12-01
Col·lecció:RNA Biology
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Accés en línia:http://dx.doi.org/10.1080/15476286.2023.2231280
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