Discovery of New Small Molecule Hits as Hepatitis B Virus Capsid Assembly Modulators: Structure and Pharmacophore-Based Approaches

Hepatitis B virus (HBV) capsid assembly modulators (CpAMs) have shown promise as potent anti-HBV agents in both preclinical and clinical studies. Herein, we report our efforts in identifying novel CpAM hits via a structure-based virtual screening against a small molecule protein-protein interaction...

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Autores principales:	Sameera Senaweera, Haijuan Du, Huanchun Zhang, Karen A. Kirby, Philip R. Tedbury, Jiashu Xie, Stefan G. Sarafianos, Zhengqiang Wang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2021-04-01
Colección:	Viruses
Materias:	Hepatitis B virus capsid assembly modulators virtual screening, protein–protein interaction pharmacophore modelling
Acceso en línea:	https://www.mdpi.com/1999-4915/13/5/770
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