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Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid Modulators

HIV-1 capsid (CA) performs multiple roles in the viral life cycle and is a promising target for antiviral development. In this work, we describe the design, synthesis, assessment of antiviral activity, and mechanistic investigation of 20 piperazinone phenylalanine derivatives with a terminal indole...

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Principais autores: Shujing Xu, Lin Sun, Waleed A. Zalloum, Tianguang Huang, Xujie Zhang, Dang Ding, Xiaoyu Shao, Xiangyi Jiang, Fabao Zhao, Simon Cocklin, Erik De Clercq, Christophe Pannecouque, Alexej Dick, Xinyong Liu, Peng Zhan
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-12-01
coleção:Molecules
Assuntos:
HIV-1
PF74
capsid modulators
target identification
mechanistic investigation
Acesso em linha:https://www.mdpi.com/1420-3049/27/23/8415
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