Computationally Assisted Lead Optimization of Novel Potent and Selective MAO-B Inhibitors
A series of dietary flavonoid acacetin 7-<i>O</i>-methyl ether derivatives were computationally designed aiming to improve the selectivity and potency profiles against monoamine oxidase (MAO) B. The designed compounds were evaluated for their potential to inhibit human MAO-A and -B. Compounds <b>1c<...
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| Asıl Yazarlar: | , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
MDPI AG
2021-09-01
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| Seri Bilgileri: | Biomedicines |
| Konular: | |
| Online Erişim: | https://www.mdpi.com/2227-9059/9/10/1304 |
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