Computationally Assisted Lead Optimization of Novel Potent and Selective MAO-B Inhibitors

A series of dietary flavonoid acacetin 7-<i>O</i>-methyl ether derivatives were computationally designed aiming to improve the selectivity and potency profiles against monoamine oxidase (MAO) B. The designed compounds were evaluated for their potential to inhibit human MAO-A and -B. Compounds <b>1c<...

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Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Vedanjali Gogineni, Manal A. Nael, Narayan D. Chaurasiya, Khaled M. Elokely, Christopher R. McCurdy, John M. Rimoldi, Stephen J. Cutler, Babu L. Tekwani, Francisco León
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	MDPI AG 2021-09-01
Σειρά:	Biomedicines
Θέματα:	flavonoids Parkinson’s Disease monoamine oxidases A and B acacetin docking
Διαθέσιμο Online:	https://www.mdpi.com/2227-9059/9/10/1304
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