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The Right Key, the Wrong Lock: TIGIT Checkpoint Blockade and the Road to Precision Immunotherapy

T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domains (TIGIT) emerged as one of the most promising next-generation immune checkpoint targets following the success of programmed cell death protein 1 (PD-1), programmed death-ligand 1 (PD-L1), and c...

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Principais autores: Shukur Wasman Smail, Hawro Taha Hamza, Mohammed Awat Ali, Raya Kh. Yashooa, Wissam Albeer Nooh, Ahmed Abdulrazzaq Bapir, Dlzar B. Rahman, Mohammed O. Rahman, Hiba A. Haseeb, Nivar B. Maaruf, Shadyar O. Majeed, Iman Ezzat, Christer Janson
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-08-01
Serier:Pharmaceutics
Fag:
TIGIT
CD155
CD226
immune checkpoint blockade
precision immunotherapy
tumor microenvironment
Online adgang:https://www.mdpi.com/1999-4923/18/8/970
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