Inhibition of epigenetic reader proteins by apabetalone counters inflammation in activated innate immune cells from Fabry disease patients receiving enzyme replacement therapy

Abstract Fabry disease (FD) is a rare X‐linked disorder of lipid metabolism, characterized by the accumulation of globotriaosylceramide (Gb3) due to defective the lysosomal enzyme, α‐galactosidase. Gb3 deposits activate immune‐mediated systemic inflammation, ultimately leading to life‐threatening co...

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Detaylı Bibliyografya

Asıl Yazarlar:	Li Fu, Sylwia Wasiak, Laura M. Tsujikawa, Brooke D. Rakai, Stephanie C. Stotz, Norman C. W. Wong, Jan O. Johansson, Michael Sweeney, Connie M. Mohan, Aneal Khan, Ewelina Kulikowski
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Wiley 2022-06-01
Seri Bilgileri:	Pharmacology Research & Perspectives
Konular:	apabetalone BETi epigenetics Fabry disease inflammation oxidative stress
Online Erişim:	https://doi.org/10.1002/prp2.949
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