The BET inhibitor apabetalone decreases neuroendothelial proinflammatory activation in vitro and in a mouse model of systemic inflammation

Brain vascular inflammation is characterized by endothelial activation and immune cell recruitment to the blood vessel wall, potentially causing a breach in the blood – brain barrier, brain parenchyma inflammation, and a decline of cognitive function. The clinical-stage small molecule, apabetalone,...

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Autors principals:	Wasiak Sylwia, Fu Li, Daze Emily, Gilham Dean, Rakai Brooke D., Stotz Stephanie C., Tsujikawa Laura M., Sarsons Chris D., Studer Deborah, Rinker Kristina D., Jahagirdar Ravi, Wong Norman C. W., Sweeney Michael, Johansson Jan O., Kulikowski Ewelina
Format:	Artigo
Idioma:	Inglês
Publicat:	De Gruyter 2023-12-01
Col·lecció:	Translational Neuroscience
Matèries:	blood–brain barrier epigenetics inflammation bromodomain microvascular disease
Accés en línia:	https://doi.org/10.1515/tnsci-2022-0332
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