Liraglutide ameliorates oxidized LDL-induced endothelial dysfunction by GLP-1R-dependent downregulation of LOX-1-mediated oxidative stress and inflammation

ABSTRACTObjective To investigate the effects of glucagon-like peptide 1 receptor (GLP-1R) agonist liraglutide on endothelial dysfunction in LDL receptor-deficient (LDLR-KO) mice and ox-LDL-challenged human umbilical vein endothelial cells (HUVECs) and its possible mechanism.Methods LDLR-KO mice were...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Wu Ying, Song Meiyan, Chen Wen, Xu Kaizu, Wu Meifang, Lin Liming
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Taylor & Francis Group 2023-12-01
Sarja:	Redox Report
Aiheet:	Liraglutide oxidized low-density lipoprotein lectin-like ox-LDL receptor-1 endothelial dysfunction oxidative stress inflammation
Linkit:	https://www.tandfonline.com/doi/10.1080/13510002.2023.2218684
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