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Liraglutide ameliorates oxidized LDL-induced endothelial dysfunction by GLP-1R-dependent downregulation of LOX-1-mediated oxidative stress and inflammation

ABSTRACTObjective To investigate the effects of glucagon-like peptide 1 receptor (GLP-1R) agonist liraglutide on endothelial dysfunction in LDL receptor-deficient (LDLR-KO) mice and ox-LDL-challenged human umbilical vein endothelial cells (HUVECs) and its possible mechanism.Methods LDLR-KO mice were...

Ful tanımlama

Kaydedildi:
Asıl Yazarlar: Wu Ying, Song Meiyan, Chen Wen, Xu Kaizu, Wu Meifang, Lin Liming
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Taylor & Francis Group 2023-12-01
Seri Bilgileri:Redox Report
Konular:
Liraglutide
oxidized low-density lipoprotein
lectin-like ox-LDL receptor-1
endothelial dysfunction
oxidative stress
inflammation
Online Erişim:https://www.tandfonline.com/doi/10.1080/13510002.2023.2218684
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