Cracking the code of cancer immunotherapy resistance: emerging roles of pyroptosis and necroptosis

Abstract Therapeutic resistance and recurrent metastasis continue to pose major obstacles in the treatment of malignant tumors worldwide. Immunogenic cell death (ICD), characterized by its ability to both eliminate cancer cells and stimulate antitumor immune responses, has emerged as a promising str...

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Detalhes bibliográficos

Principais autores:	Kunming Lei, Jiujiu Chen, Yanrong Deng, Yige Peng, Xiang Zhai, Xianghai Ren, Jianhong Zhao, Baoxiang Chen, Congqing Jiang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-11-01
coleção:	Journal of Experimental & Clinical Cancer Research
Assuntos:	Cancer immunotherapy resistance Immunogenic cell death Pyroptosis Necroptosis Tumor microenvironment
Acesso em linha:	https://doi.org/10.1186/s13046-025-03569-3
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