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Evidence for an Integrated Gene Repression Mechanism Based on mRNA Isoform Toggling in Human Cells

We recently described an unconventional mode of gene regulation in budding yeast by which transcriptional and translational interference collaborate to down-regulate protein expression. Developmentally timed transcriptional interference inhibited production of a well translated mRNA isoform and resu...

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Bibliografiska uppgifter
Huvudupphov: Ina Hollerer, Juliet C. Barker, Victoria Jorgensen, Amy Tresenrider, Claire Dugast-Darzacq, Leon Y. Chan, Xavier Darzacq, Robert Tjian, Elçin Ünal, Gloria A. Brar
Materialtyp: Artigo
Språk:Inglês
Utgiven: Oxford University Press 2019-04-01
Serie:G3: Genes, Genomes, Genetics
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Länkar:http://g3journal.org/lookup/doi/10.1534/g3.118.200802
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