The open architecture of HD-PTP phosphatase provides new insights into the mechanism of regulation of ESCRT function
Abstract HD-PTP is a tumour suppressor phosphatase that controls endocytosis, down-regulation of mitogenic receptors and cell migration. Central to its role is the specific recruitment of critical endosomal sorting complexes required for transport (ESCRTs). However, the molecular mechanisms that ena...
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| Principais autores: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Portfolio
2017-08-01
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| 叢編: | Scientific Reports |
| 在線閱讀: | https://doi.org/10.1038/s41598-017-09467-9 |
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