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Deciphering the inhibitory effects of trimetazidine on pulmonary hypertension development via decreasing fatty acid oxidation and promoting glucose oxidation

Abstract Pulmonary hypertension (PH) is a devastating disease characterized by vascular remodeling, resulting in right ventricular failure and death. Dysregulation of energy metabolism is linked to PH pathogenesis. Trimetazidine (TMZ), a selective long-chain 3-ketoacyl coenzyme A thiolase inhibitor,...

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Wedi'i Gadw mewn:
Prif Awduron: Asako Yanagisawa, Jun-Dal Kim, Akira Naito, Takayuki Kobayashi, Tomoko Misawa, Seiichiro Sakao, Takayuki Jujo-Sanada, Takeshi Kawasaki, Shin-ichi Muroi, So-Ichiro Sasaki, Takuji Suzuki, Yoshihiro Hayakawa, Yoshimi Nakagawa, Yoshitoshi Kasuya, Koichiro Tatsumi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Portfolio 2024-11-01
Cyfres:Scientific Reports
Pynciau:
Pulmonary hypertension
Trimetazidine
Pulmonary transcriptome
Cardiac metabolome
SU5416-hypoxia
Mynediad Ar-lein:https://doi.org/10.1038/s41598-024-76100-x
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