Deciphering the inhibitory effects of trimetazidine on pulmonary hypertension development via decreasing fatty acid oxidation and promoting glucose oxidation

Abstract Pulmonary hypertension (PH) is a devastating disease characterized by vascular remodeling, resulting in right ventricular failure and death. Dysregulation of energy metabolism is linked to PH pathogenesis. Trimetazidine (TMZ), a selective long-chain 3-ketoacyl coenzyme A thiolase inhibitor,...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Asako Yanagisawa, Jun-Dal Kim, Akira Naito, Takayuki Kobayashi, Tomoko Misawa, Seiichiro Sakao, Takayuki Jujo-Sanada, Takeshi Kawasaki, Shin-ichi Muroi, So-Ichiro Sasaki, Takuji Suzuki, Yoshihiro Hayakawa, Yoshimi Nakagawa, Yoshitoshi Kasuya, Koichiro Tatsumi
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Nature Portfolio 2024-11-01
Sarja:	Scientific Reports
Aiheet:	Pulmonary hypertension Trimetazidine Pulmonary transcriptome Cardiac metabolome SU5416-hypoxia
Linkit:	https://doi.org/10.1038/s41598-024-76100-x
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