Two Amino Acid Substitutions Improve the Pharmacological Profile of the Snake Venom Peptide Mambalgin
Mambalgins are peptide inhibitors of acid-sensing ion channels type 1 (ASIC1) with potent analgesic effects in models of inflammatory and neuropathic pain. To optimize recombinant peptide production and enhance pharmacological properties, we developed a mutant analog of mambalgin-1 (Mamb) through mo...
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| Автори: | , , , , , , , , , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
MDPI AG
2025-02-01
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| Серія: | Toxins |
| Предмети: | |
| Онлайн доступ: | https://www.mdpi.com/2072-6651/17/3/101 |
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