Potential Ameliorating Role of Spironolactone in Trastuzumab-induced Cardiotoxicity: A Narrative Review

Background: Around 20% of breast cancers (BCs) overexpress Human Epidermal Growth Factor Receptor 2 (HER-2). HER-2 overexpression is associated with increased tumor aggressiveness and poor prognosis. Trastuzumab (an anti-HER2 monoclonal antibody) has been reported to improve overall survival in earl...

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Autors principals:	Amir Ghabousian, Azin Alizadehasl, Niloufar Ansari, Mehrdad Haghazali
Format:	Artigo
Idioma:	Inglês
Publicat:	Shaheed Beheshti University of Medical Sciences 2021-11-01
Col·lecció:	International Journal of Medical Toxicology and Forensic Medicine
Matèries:	spironolactone trastuzumab cardiotoxicity heart failure cardio-oncology chemotherapy mitochondria oxidative stress
Accés en línia:	https://journals.sbmu.ac.ir/ijmtfm/article/view/36127
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