Identification of ethyl pyruvate as a NLRP3 inflammasome inhibitor that preserves mitochondrial integrity

Abstract Background The NLRP3 inflammasome, a cytosolic complex that mediates the maturation of IL-1β and IL-18 as well as the release of high mobility group box 1 (HMGB1), contributes to the lethality of endotoxic shock. Ethyl pyruvate (EP) was previously shown to inhibit HMGB1 release and promote...

Descripció completa

Dades bibliogràfiques

Autors principals:	Sujun Li, Fang Liang, Kevin Kwan, Yiting Tang, Xiangyu Wang, Youzhou Tang, Jianhua Li, Huan Yang, Sangeeta S. Chavan, Haichao Wang, Ulf Andersson, Ben Lu, Kevin J. Tracey
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2018-03-01
Col·lecció:	Molecular Medicine
Matèries:	Ethyl pyruvate The NLRP3 inflammasomes Mitochondrial damage HMGB1 Interleukin-1beta
Accés en línia:	http://link.springer.com/article/10.1186/s10020-018-0006-9
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!