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Fusion peptide priming reduces immune responses to HIV-1 envelope trimer base

Summary: Soluble “SOSIP”-stabilized envelope (Env) trimers are promising HIV-vaccine immunogens. However, they induce high-titer responses against the glycan-free trimer base, which is occluded on native virions. To delineate the effect on base responses of priming with immunogens targeting the fusi...

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Principais autores: Angela R. Corrigan, Hongying Duan, Cheng Cheng, Christopher A. Gonelli, Li Ou, Kai Xu, Megan E. DeMouth, Hui Geng, Sandeep Narpala, Sarah O’Connell, Baoshan Zhang, Tongqing Zhou, Manjula Basappa, Jeffrey C. Boyington, Steven J. Chen, Sijy O’Dell, Amarendra Pegu, Tyler Stephens, Yaroslav Tsybovsky, Jelle van Schooten, John P. Todd, Shuishu Wang, Nicole A. Doria-Rose, Kathryn E. Foulds, Richard A. Koup, Adrian B. McDermott, Marit J. van Gils, Peter D. Kwong, John R. Mascola
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021-04-01
coleção:Cell Reports
Assuntos:
fusion peptide
HIV vaccine
immune response
immunization regimen
immunogen cocktail
nanoparticle immunogen
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211124721002515
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