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Host factor Rab4b mediates internalization and intoxication of 3D4/21 cells by the active subunit of the Glaesserella parasuis cytolethal distending toxin via influencing EEA1 expression

BackgroundThe cytolethal distending toxin (CDT), a significant exotoxin, is closely linked to the pathogenicity of Glaesserella parasuis (GPS), but its pathogenic not yet fully elucidated. Previously, we identified Rab4b as a potential host factor contributing to the cytotoxicity of GpCDT through a...

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Principais autores: Yiwen Zhang, Zhen Yang, Senyan Du, Qin Zhao, Xiaobo Huang, Rui Wu, Yiping Wang, Qigui Yan, Sanjie Cao, Yiping Wen
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-10-01
Serier:Frontiers in Microbiology
Fag:
Glaesserella parasuis
Rab4b
GpCDT
EEA1
vesicle trafficking
Online adgang:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1660176/full
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