NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis

Abstract NSP7 (Non‐Structural Protein 7) of SARS‐CoV‐2 is a crucial component for viral replication and transcription. In this study, it is revealed that the host E3 ubiquitin ligase FBXO5 suppresses viral replication by mediating NSP7 lysine‐48‐linked ubiquitination and subsequent proteasomal degra...

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Autori principali:	Yao Tong, Travis B. Lear, Ferhan Tuncer, John J. Villandre, Áine N. Boudreau, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Daniel P. Camarco, Mads B. Larsen, Yun Hua, Yanwen Chen, Meigin E. Chandler, Ricardo Pineda, Simon M. Barratt‐Boyes, John W. Evankovich, Toren Finkel, Yuan Liu, Bill B. Chen
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley 2025-09-01
Serie:	Advanced Science
Soggetti:	antiviral therapies β‐TrCP1 FBXO5 non‐structural protein 7 TAF1 ubiquitination
Accesso online:	https://doi.org/10.1002/advs.202500798
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