NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis

Abstract NSP7 (Non‐Structural Protein 7) of SARS‐CoV‐2 is a crucial component for viral replication and transcription. In this study, it is revealed that the host E3 ubiquitin ligase FBXO5 suppresses viral replication by mediating NSP7 lysine‐48‐linked ubiquitination and subsequent proteasomal degra...

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Hlavní autoři:	Yao Tong, Travis B. Lear, Ferhan Tuncer, John J. Villandre, Áine N. Boudreau, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Daniel P. Camarco, Mads B. Larsen, Yun Hua, Yanwen Chen, Meigin E. Chandler, Ricardo Pineda, Simon M. Barratt‐Boyes, John W. Evankovich, Toren Finkel, Yuan Liu, Bill B. Chen
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2025-09-01
Edice:	Advanced Science
Témata:	antiviral therapies β‐TrCP1 FBXO5 non‐structural protein 7 TAF1 ubiquitination
On-line přístup:	https://doi.org/10.1002/advs.202500798
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