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Pachymic acid alleviates metabolic dysfunction-associated steatotic liver disease by inhibiting ferroptosis through PPARα

IntroductionMetabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by excessive lipid deposition in hepatocytes without a history of significant alcohol consumption. Pachymic acid (Pac), a bioactive triterpenoid from Poria cocos, has shown promise in treating MASLD due to...

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Hoofdauteurs: Guilin Ren, Yiyou Lin, Jiannan Qiu, Congcong Zhang, Lin Chen, Linwensi Zhu, Xiaohui Fan, Xiaobing Dou, Qingsheng Liu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2025-05-01
Reeks:Frontiers in Pharmacology
Onderwerpen:
pachymic acid
metabolic dysfunction-associated steatotic liver disease
ferroptosis
PPARα
MAPKs signaling pathway
Online toegang:https://www.frontiersin.org/articles/10.3389/fphar.2025.1554850/full
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