Strategies to Target ISG15 and USP18 Toward Therapeutic Applications
The interferon (IFN)-stimulated gene product 15 (ISG15) represents an ubiquitin-like protein (Ubl), which in a process termed ISGylation can be covalently linked to target substrates via a cascade of E1, E2, and E3 enzymes. Furthermore, ISG15 exerts functions in its free form both, as an intracellul...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
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Frontiers Media S.A.
2020-01-01
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| Schriftenreihe: | Frontiers in Chemistry |
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| Online-Zugang: | https://www.frontiersin.org/article/10.3389/fchem.2019.00923/full |
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