ISG15/USP18/STAT2 is a molecular hub regulating IFN I-mediated control of Dengue and Zika virus replication

The establishment of a virus infection is the result of the pathogen's ability to replicate in a hostile environment generated by the host's immune system. Here, we found that ISG15 restricts Dengue and Zika viruses' replication through the stabilization of its binding partner USP18. ISG15 expressio...

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Principais autores:	Constanza Eleonora Espada, Edroaldo Lummertz da Rocha, Taissa Ricciardi-Jorge, Adara Aurea dos Santos, Zamira Guerra Soares, Greicy Malaquias, Daniel Oliveira Patrício, Edgar Gonzalez Kozlova, Paula Fernandes dos Santos, Juliano Bordignon, Thomas J. Sanford, Teodoro Fajardo, Trevor R. Sweeney, André Báfica, Daniel Santos Mansur
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2024-02-01
Serija:	Frontiers in Immunology
Teme:	Dengue virus Zika virus ISG15 USP18 type one interferon ISGylation
Online dostop:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1331731/full
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