A diagnostic signature derived from NK cell related genes in prostate cancer: insights from integrated scRNA-seq and bulk RNA-seq analyses with functional validation of KIT

BackgroundProstate cancer is one of the most common malignant tumors of the male genitourinary system. The impaired activity of natural killer (NK) cells observed in prostate cancer may contribute to immune evasion. This study aimed to develop robust NK cell-related diagnostic signatures.MethodsBase...

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Principais autores:	Zhengjun Chen, Fang Zhou, Jingzhi Tian, Qian Lv, Dong Wang, Shida Fan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-06-01
Colecção:	Frontiers in Immunology
Assuntos:	diagnostic model immunotherapy NK cell marker genes prostate cancer single-cell and bulk RNA-sequencing
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1692792/full
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