Elucidating the direct effects of the novel HDAC inhibitor bocodepsin (OKI-179) on T cells to rationally design regimens for combining with immunotherapy

Histone deacetylase inhibitors (HDACi) are currently being explored for the treatment of both solid and hematological malignancies. Although originally thought to exert cytotoxic responses through tumor-intrinsic mechanisms by increasing expression of tumor suppressor genes, several studies have dem...

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Үндсэн зохиолчид:	Nisha Holay, Alexander Somma, Mark Duchow, Milad Soleimani, Anna Capasso, Srividya Kottapalli, Joshua Rios, Uma Giri, Jennifer Diamond, Anna Schreiber, Anthony D. Piscopio, Carla Van Den Berg, S. Gail Eckhardt, Todd A. Triplett
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2023-09-01
Цуврал:	Frontiers in Immunology
Нөхцлүүд:	T cell colorectal cancer HDAC HDAC inhibitors cancer immunotherapy
Онлайн хандалт:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1260545/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!