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Metabolic and Stress Response Changes Precede Disease Onset in the Spinal Cord of Mutant SOD1 ALS Mice

Many Amyotrophic Lateral Sclerosis (ALS) patients experience hypermetabolism, or an increase in measured vs. calculated metabolic rate. The cause of hypermetabolism and the effects on neuronal metabolism in ALS are currently unknown, but the efficacy of dietary interventions shows promise for metabo...

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Principais autores: Gavin Pharaoh, Kavithalakshmi Sataranatarajan, Kaitlyn Street, Shauna Hill, Jake Gregston, Bumsoo Ahn, Caroline Kinter, Michael Kinter, Holly Van Remmen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-05-01
coleção:Frontiers in Neuroscience
Assuntos:
amyotrophic lateral sclerosis (ALS)
SOD1G93A ALS mouse model
metabolism
hypermetabolism
mitochondria
antioxidants
Acesso em linha:https://www.frontiersin.org/article/10.3389/fnins.2019.00487/full
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