Bicistronic CAR-T cells targeting CD123 and CLL1 for AML to reduce the risk of antigen escape

Purpose: Acute myeloid leukemia (AML) is a highly heterogeneous neoplastic disease with a poor prognosis that relapses even after its treatment with chimeric antigen receptor (CAR)-T cells targeting a single antigen. CD123 and CLL1 are expressed in most AML blasts and leukemia stem cells, and their...

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Hlavní autoři:	Danni Xie, Xin Jin, Rui Sun, Meng Zhang, Wenyi Lu, Xinping Cao, Ruiting Guo, Yi Zhang, Mingfeng Zhao
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2023-08-01
Edice:	Translational Oncology
Témata:	Acute myeloid leukemia CD123 C-type lectin-like molecule-1 Chimeric antigen receptor Immunotherapy
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S1936523323000815
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