MDA5 variants trade antiviral activity for protection from autoimmune disease
Abstract Loss-of-function variants in MDA5, a key sensor of double-stranded RNA from viruses and retroelements, have been associated with protection from type 1 diabetes (T1D) in genome-wide association studies (GWAS). MDA5 loss-of-function variants have also been reported to increase the risk of in...
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| Hoofdauteurs: | , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
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BMC
2025-06-01
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| Reeks: | BMC Medical Genomics |
| Onderwerpen: | |
| Online toegang: | https://doi.org/10.1186/s12920-025-02171-y |
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