Distributed clonal deletion prevents autoimmune disease progression

Summary: Self-reactive B cells arise during development and can increase pathogenicity through activation-induced cytidine deaminase (AID)-mediated diversification. Clonal deletion is thought to eliminate these cells, yet how deletion is distributed across developmental and activation stages to prev...

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Principais autores:	Anna M. Newen, Uzair A. Ansari, Mikala J. Simpson, Fiona Flynn, Sukriti Sharma, Michael Ivanov, Ishaan Antani, Dylan Pfannenstiel, Baktiar Karim, Laura Bassel, Brian Capaldo, Qingrong Chen, Daoud Meerzaman, Indu Raman, Chengsong Zhu, Cornelius Y. Taabazuing, Hamid Kashkar, Christian T. Mayer
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2026-08-01
Serija:	Cell Reports
Teme:	CP: immunology
Online dostop:	http://www.sciencedirect.com/science/article/pii/S2211124726008016
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