Halofuginone Disrupted Collagen Deposition via mTOR‐eIF2α‐ATF4 Axis to Enhance Chemosensitivity in Ovarian Cancer

Abstract The interplay between cancer‐associated fibroblasts (CAFs) and extracellular matrix (ECM) mediates progress, metastasis, and therapy resistance. However, strategy of targeting ECM remodeling to enhance chemosensitivity in ovarian cancer remains elusive. Here, a 22‐gene matrisome signature p...

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Autors principals:	Wenxin Li, Yenan Wu, Yanan Zhang, Wenyan Gao, Xin Li, Haixia Luo, Mengmeng Lu, Zhihua Liu, Aiping Luo
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2025-05-01
Col·lecció:	Advanced Science
Matèries:	cancer‐associated fibroblasts (CAFs) COL1A1 extracellular matrix fibrosis halofuginone ovarian cancer
Accés en línia:	https://doi.org/10.1002/advs.202416523
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