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Halofuginone Disrupted Collagen Deposition via mTOR‐eIF2α‐ATF4 Axis to Enhance Chemosensitivity in Ovarian Cancer

Abstract The interplay between cancer‐associated fibroblasts (CAFs) and extracellular matrix (ECM) mediates progress, metastasis, and therapy resistance. However, strategy of targeting ECM remodeling to enhance chemosensitivity in ovarian cancer remains elusive. Here, a 22‐gene matrisome signature p...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Wenxin Li, Yenan Wu, Yanan Zhang, Wenyan Gao, Xin Li, Haixia Luo, Mengmeng Lu, Zhihua Liu, Aiping Luo
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Wiley 2025-05-01
Rangatū:Advanced Science
Ngā marau:
cancer‐associated fibroblasts (CAFs)
COL1A1
extracellular matrix
fibrosis
halofuginone
ovarian cancer
Urunga tuihono:https://doi.org/10.1002/advs.202416523
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