The postnatal injection of AAV9-FOXG1 rescues corpus callosum agenesis and other brain deficits in the mouse model of FOXG1 syndrome

Heterozygous mutations in the FOXG1 gene manifest as FOXG1 syndrome, a severe neurodevelopmental disorder characterized by structural brain anomalies, including agenesis of the corpus callosum, hippocampal reduction, and myelination delays. Despite the well-defined genetic basis of FOXG1 syndrome, t...

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Váldodahkkit:	Shin Jeon, Jaein Park, Shibi Likhite, Ji Hwan Moon, Dongjun Shin, Liwen Li, Kathrin C. Meyer, Jae W. Lee, Soo-Kyung Lee
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Elsevier 2024-09-01
Ráidu:	Molecular Therapy: Methods & Clinical Development
Fáttát:	FOXG1 AAV9 gene therapy corpus callosum dentate gyrus oligodendrocytes
Liŋkkat:	http://www.sciencedirect.com/science/article/pii/S2329050124000913
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