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The postnatal injection of AAV9-FOXG1 rescues corpus callosum agenesis and other brain deficits in the mouse model of FOXG1 syndrome

Heterozygous mutations in the FOXG1 gene manifest as FOXG1 syndrome, a severe neurodevelopmental disorder characterized by structural brain anomalies, including agenesis of the corpus callosum, hippocampal reduction, and myelination delays. Despite the well-defined genetic basis of FOXG1 syndrome, t...

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Principais autores: Shin Jeon, Jaein Park, Shibi Likhite, Ji Hwan Moon, Dongjun Shin, Liwen Li, Kathrin C. Meyer, Jae W. Lee, Soo-Kyung Lee
פורמט: Artigo
שפה:Inglês
יצא לאור: Elsevier 2024-09-01
סדרה:Molecular Therapy: Methods & Clinical Development
נושאים:
FOXG1
AAV9
gene therapy
corpus callosum
dentate gyrus
oligodendrocytes
גישה מקוונת:http://www.sciencedirect.com/science/article/pii/S2329050124000913
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